Sarcomas of the Skull Base
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Specialists in the Field of Sarcomas of the Skull Base
Radiological Alliance – Interdisciplinary Center for Radiosurgery
Radiation Therapy / Gamma Knife
Information About the Field of Sarcomas of the Skull Base
What Are Sarcomas of the Skull Base?
Sarcomas are rare malignant tumors that arise from mesenchymal tissue. These tumors can arise from connective tissue, muscle, fatty tissue, bone, and cartilage. Sarcomas are rare and account for less than 1% of new cancer cases per year in Germany. Sarcomas of the skull base arise from bone tissue. The challenge in treating these sarcomas is their anatomical proximity to critical structures such as the brainstem, optic nerves, and temporal lobe.
What Are the Different Types?
Seventy-nine types of soft tissue sarcomas are distinguished, of which 61 are considered malignant. Three different types of sarcomas can arise from bone tissue: chondrosarcoma s , Ewing sarcomas, and osteosarcomas . Sarcomas of the skull base are usually osteosarcomas or Ewing sarcomas.
Diagnosis and Treatment
If a sarcoma is suspected, extensive examinations by various specialists are necessary. First, it must be diagnosed whether it is a sarcoma, and second, the size and spread must be determined. Imaging techniques are best suited for this purpose. Magnetic resonance imaging can provide the best information. The spread, location, and differentiation to neighboring structures can be visualized.
A tissue sample, known as a biopsy, must be taken from the tumor. Pathology physicians examine this sample under a microscope, and various procedures determine its origin. In this way, the diagnosis of sarcoma can be confirmed. Once the diagnosis is established, the body must be systematically searched for possible metastases with imaging techniques. For example, computed tomography is well suited for examining the lungs, while magnetic resonance imaging provides better insight into the abdominal cavity. Finally, the skeleton is examined using whole-body skeletal scintigraphy . Depending on the findings, further examinations may be arranged.
Patients are assigned to different risk groups based on their prognostic factors. The individual treatment plan is based on this allocation. The decision on the treatment plan is discussed in an interdisciplinary sarcoma board in a tumor center. The treatment of choice is the complete surgical removal of the sarcoma with chemotherapy , which is carried out before or after surgery. In addition, for some types of sarcoma, radiation using proton therapy , gamma knife, or cyberknife may contribute to treatment success.
Cure and Prognosis
The prognosis depends on many variables. The tumor size and stage at the start of therapy, the patient's age and physical condition, and the outcome of surgical removal all play a role. If the sarcoma can be entirely removed by surgery, the chances of recovery are good. Depending on the type of bone sarcoma, the 5-year survival rate is 50-75%.
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